pathophysiological alterations after vaccination with COVID-19 vaccines

 

Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines

• Jiping Liu, 
• Junbang Wang, 
• […]
• Zhongmin Liu 

• • Abstract

    Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in COVID-19 patients, suggesting that vaccination mimicked an infection. Single-cell mRNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) before and 28 days after the first inoculation also revealed consistent alterations in gene expression of many different immune cell types. Reduction of CD8+ T cells and increase in classic monocyte contents were exemplary. Moreover, scRNA-seq revealed increased NF-κB signaling and reduced type I interferon responses, which were confirmed by biological assays and also had been reported to occur after SARS-CoV-2 infection with aggravating symptoms. Altogether, our study recommends additional caution when vaccinating people with pre-existing clinical conditions, including diabetes, electrolyte imbalances, renal dysfunction, and coagulation disorders.

  • Our study postulates that it is imperative to consider the potential long-term

  •  impact of vaccination to certain medical conditions34 or to general human health.

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  • https://www.nature.com/articles/s41421-021-00329-3

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